H2N2V1, Main, Exploration, bibRecord, 002199

Gamma-irradiated influenza A virus can prime for a cross-reactive and cross-protective immune response against influenza A viruses.

Identifieur interne : 002199 ( Main/Exploration ); précédent : 002198; suivant : 002200

Gamma-irradiated influenza A virus can prime for a cross-reactive and cross-protective immune response against influenza A viruses.

Auteurs : A. Müllbacher ; G L Ada ; R T Hla

Source :

Immunology and cell biology [ 0818-9641 ] ; 1988.

RBID : pubmed:2846435

Descripteurs français

KwdFr :
- Animaux, Femelle, Immunité (effets des radiations), Infections à Orthomyxoviridae (immunologie), Lymphocytes T cytotoxiques (immunologie), Mâle, Rayons gamma, Réactions croisées, Souris, Souris de lignée BALB C, Virus de la grippe A (effets des radiations), Virus de la grippe A (immunologie).
MESH :
- effets des radiations : Immunité, Virus de la grippe A.
- immunologie : Infections à Orthomyxoviridae, Lymphocytes T cytotoxiques, Virus de la grippe A.
- Animaux, Femelle, Mâle, Rayons gamma, Réactions croisées, Souris, Souris de lignée BALB C.

English descriptors

KwdEn :
- Animals, Cross Reactions, Female, Gamma Rays, Immunity (radiation effects), Influenza A virus (immunology), Influenza A virus (radiation effects), Male, Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (immunology), T-Lymphocytes, Cytotoxic (immunology).
MESH :
- immunology : Influenza A virus, Orthomyxoviridae Infections, T-Lymphocytes, Cytotoxic.
- radiation effects : Immunity, Influenza A virus.
- Animals, Cross Reactions, Female, Gamma Rays, Male, Mice, Mice, Inbred BALB C.

Abstract

A-strain influenza virus A/JAP (H2N2) was tested for its ability to induce cytotoxic T cells (Tc) after being rendered non-infectious by either UV or gamma irradiation. Gamma-irradiated virus proved to be more efficient than UV-inactivated virus in priming for a memory Tc cell response or in boosting memory spleen cells in vitro. Most importantly, gamma-inactivated, but not UV-inactivated, A/JAP immunized animals survived lethal challenge with heterologous (A/PC(H3N2), A/WSN(H1N1)) virus as effectively as mice primed with infectious virus.

DOI: 10.1038/icb.1988.19
PubMed: 2846435

Affiliations:

Le document en format XML

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<series><title level="j">Immunology and cell biology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
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<term>Influenza A virus (immunology)</term>
<term>Influenza A virus (radiation effects)</term>
<term>Male</term>
<term>Mice</term>
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<term>Orthomyxoviridae Infections (immunology)</term>
<term>T-Lymphocytes, Cytotoxic (immunology)</term>
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<term>Femelle</term>
<term>Immunité (effets des radiations)</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Lymphocytes T cytotoxiques (immunologie)</term>
<term>Mâle</term>
<term>Rayons gamma</term>
<term>Réactions croisées</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Virus de la grippe A (effets des radiations)</term>
<term>Virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des radiations" xml:lang="fr"><term>Immunité</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
<term>Lymphocytes T cytotoxiques</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A virus</term>
<term>Orthomyxoviridae Infections</term>
<term>T-Lymphocytes, Cytotoxic</term>
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<term>Influenza A virus</term>
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<term>Cross Reactions</term>
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<term>Mice</term>
<term>Mice, Inbred BALB C</term>
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<term>Mâle</term>
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<name sortKey="Mullbacher, A" sort="Mullbacher, A" uniqKey="Mullbacher A" first="A" last="Müllbacher">A. Müllbacher</name>
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Serveur d'exploration H2N2

Gamma-irradiated influenza A virus can prime for a cross-reactive and cross-protective immune response against influenza A viruses.

Gamma-irradiated influenza A virus can prime for a cross-reactive and cross-protective immune response against influenza A viruses.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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